• Nanjing Decry Pharmaceutical Chemicals Co., Ltd.
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    5-Azacytidine
    Product name:
    5-Azacytidine
    CAS NO.:
    320-67-2
    EINECS NO.:
    206-280-2
    Molecular formula:
    C8H12N4O5
    Molecular weight:
    244.2047
    Molecular Structure:
    Physicochemical properties:
    This product is a pyrimidine nucleoside analog produced by the microorganism Streptoverticillium ladakanus, and can also be synthesized chemically. It is a cell cycle-specific drug that acts on S phase, and can rapidly phosphorylate and incorporate RNA and DNA to inhibit protein synthesis by disrupting nucleic acid and smoothly translating into protein. Pyrimidine synthesis can also be affected by inhibition of orotate nucleotide decarboxylase.
    Uses:
    Antimetabolite. The primary indication is acute myeloid leukemia that is ineffective for conventional treatment. Also used for breast cancer, melanoma, intestinal cancer and so on. Toxicity is mainly characterized by leukopenia, thrombocytopenia and anemia. Nausea and vomiting are common side effects, which can be improved by prolonged continuous infusion, or with antiemetics from 24h to 48h before treatment. Other toxic effects are diarrhea, neuromuscular disorders, fever, hypotension, and rash. The formulation was freshly prepared 3-4 h before use.
    Hot keywords: 5-Aza-2'-deoxycytidine , 4-fluoro-1H-pyrazole , 5-Azacytidine , Retigabine , Cladribine , Tert-butyl 2,5-dihydro-1H-pyrrole-1-carboxylate...
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